LY6G6D - lymphocyte antigen 6 family member G6D Gene

Also Known as G6D; NG25; LY6-D; MEGT1; C6orf23

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 58530

About LY6G6D

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,715,348-31,717,919 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 56 orthologues and 1 paralogue. Biased expression in prostate (RPKM 1.8), testis (RPKM 1.5) and 6 other tissues.

Summary

LY6G6D belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 Amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]).[supplied by OMIM, Apr 2009]

LY6G6D Products (1)

mRNA Protein Name
NM_021246.4 NP_067069.2 lymphocyte antigen 6 complex locus protein G6d precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IDA
IDA: Inferred from direct assay
17008713 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence References Source
colocalizes with external side of plasma membrane IDA
IDA: Inferred from direct assay
17008713 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
17008713 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lymphocyte antigen 6 complex locus protein G6d

  • lymphocyte antigen 6 complex, locus G6D

LY6G6D Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LY6G6D O95868 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
LY6G6D O95868 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
LY6G6D O95868 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
LY6G6D O95868 HSPA5 Homo sapiens P11021
Anti Tag CoIP
33961781
Intra
LY6G6D O95868 NCS1 Homo sapiens P62166
Validated Y2H
32296183
Intra
LY6G6D O95868 NCALD Homo sapiens P61601
Validated Y2H
32296183
Intra
LY6G6D O95868 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LY6G6D Proteins

Cat. No. Product Name Accession Purity
HY-P71751 LY6G6D Protein, Human (P.pastoris, His) O95868 (N20-S104) ≥ 95%, as determined by reducing SDS-PAGE.

LY6G6D Antibodies

Cat. No. Product Name Application Reactivity
HY-P83879 G6D Antibody (YA3576) WB, ICC/IF, FC, ELISA Human, Mouse, Rat, Monkey
HY-P83879A G6D Antibody (YA3576)(PBS only) WB, ICC/IF, FC, ELISA Human, Mouse, Rat, Monkey

Related Diseases

Diseases Alias
Glucosephosphate Dehydrogenase Deficiency

  • G6pd Deficiency

  • Glucose-6-Phosphate Dehydrogenase Deficiency

  • Deficiency Of Glucose-6-Phosphate Dehydrogenase

  • Glucose 6 Phosphate Dehydrogenase Deficiency

  • Deficiency Of G-6pd

  • G6pdd
Anemia, Nonspherocytic Hemolytic, Due To G6pd Deficiency

  • Favism

  • Favism, Susceptibility To

  • Hemolytic Anemia, G6pd Deficient

  • Class I Glucose-6-Phosphate Dehydrogenase Deficiency

  • Class I G6pd Deficiency

  • Severe Hemolytic Anemia Due To G6pd Deficiency

  • Anemia, Non-Spherocytic Hemolytic, Due To G6pd Deficiency

  • NSHA

  • G6pd Deficient Hemolytic Anemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990925 Linclatamig Inhibitor 96.09% Phase 1

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07899 LY6G6D Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07900 LY6G6F Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19787 Ly6g6d Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26283 Ly6g6d Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris LY6G6D VGNC VGNC:106603
Rattus norvegicus LY6G6D RGD RGD:1303064
Bos taurus LY6G6D VGNC VGNC:54228
Mus musculus LY6G6D MGD MGI:2148931
Others LY6G6D NCBI